Suggestions for the Acute Management of a H5N1 Pandemic, by Spencer Feldman
The H5N1 (Asian Avian Flu or “Bird Flu”) virus owes its lethality to its ability to instigate pathological immune responses in the host via cytokine storm. This leads to disseminated intravascular coagulation (DIC) and massive infiltration of inflammatory cells into the lungs. Thus, any H5N1 protocol must take into consideration, not only the inhibition of the virus, but also the effects of DIC and alveolar flooding. Given that there are reports of some patients dying within three hours of initial symptoms, any medical response must be swift and aggressive. Traditional models for treatment outside of a hospital setting rely upon …